Example Features Table for Driver Prioritization

The example dataset containing features for prioritizing cancer driver genes for the lung adenocarcinoma patient studied in Imielinski M, Greulich H, Kaplan B, et al. Oncogenic and sorafenib-sensitive ARAF mutations in lung adenocarcinoma. J Clin Invest. 2014;124(4):1582-6.

example_features_table

Format

A data frame with 4901 rows and 27 variables:

gene_symbol: HGNC gene symbol
metaprediction_score: the maximum metapredictor (coding) impact score for the gene
noncoding_score: the maximum non-coding PHRED-scaled CADD score for the gene
scna_score: SCNA proxy score. SCNA density (SCNA/Mb) of the minimal common region (MCR) in which the gene is located
hotspot_double_hit: boolean indicating whether the gene is a hotspot gene (indication of oncogenes) or subject to double-hit (indication of tumor-suppressor genes)
phenolyzer_score: 'phenolyzer' score for the gene
hsa03320: boolean indicating whether or not the gene takes part in this KEGG pathway
hsa04010: boolean indicating whether or not the gene takes part in this KEGG pathway
hsa04020: boolean indicating whether or not the gene takes part in this KEGG pathway
hsa04024: boolean indicating whether or not the gene takes part in this KEGG pathway
hsa04060: boolean indicating whether or not the gene takes part in this KEGG pathway
hsa04066: boolean indicating whether or not the gene takes part in this KEGG pathway
hsa04110: boolean indicating whether or not the gene takes part in this KEGG pathway
hsa04115: boolean indicating whether or not the gene takes part in this KEGG pathway
hsa04150: boolean indicating whether or not the gene takes part in this KEGG pathway
hsa04151: boolean indicating whether or not the gene takes part in this KEGG pathway
hsa04210: boolean indicating whether or not the gene takes part in this KEGG pathway
hsa04310: boolean indicating whether or not the gene takes part in this KEGG pathway
hsa04330: boolean indicating whether or not the gene takes part in this KEGG pathway
hsa04340: boolean indicating whether or not the gene takes part in this KEGG pathway
hsa04350: boolean indicating whether or not the gene takes part in this KEGG pathway
hsa04370: boolean indicating whether or not the gene takes part in this KEGG pathway
hsa04510: boolean indicating whether or not the gene takes part in this KEGG pathway
hsa04512: boolean indicating whether or not the gene takes part in this KEGG pathway
hsa04520: boolean indicating whether or not the gene takes part in this KEGG pathway
hsa04630: boolean indicating whether or not the gene takes part in this KEGG pathway
hsa04915: boolean indicating whether or not the gene takes part in this KEGG pathway

Format

See also